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Stem Cells & Regenerative Medicine

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Stem Cells & Regenerative Medicine

Stem-cells are being touted to be the future of regenerative medicine. The stem cell department aims to use stem cell science to better understand and develop novel cell-based therapies for some of them through translational research including basic science, animal models for diseases and clinical trials. Humans and animals possess very small, self-renewing populations of stem cells. These vary in potential and potency, depending on developmental stage. At one extreme are embryonic stem cells, obtainable just a few cell divisions after sperm fertilizes the egg. These cells can give rise to virtually any cell type in the body. The department is headed by Dr P.M Sunil, who is a fellow in Regenerative Medicine from Toronto University, MacMaster, University of Ottowa and has also undergone training in Regenerative Medicine from Utrecht University, Netherlands.

Goals
  • Establish teams of scientists to work in specific themes directed at addressing unmet heathcare needs through carefully directed translational research.
  • Create cellular and animal models of diseases to test hypothesis generated from understanding of those diseases and of stem cell biology.
  • Perform early phase clinical trials with stem cells manufactured under current good manufacturing practice (GMP) conditions.
  • Develop a training program for students and scientists who will contribute to the manpower required for this field in the country.
Faculties
Director
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Dr. P M Sunil – MDS, PhD

Chief Research Associate
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Dr. Joseph Johny

Ongoing Projects
  • Use of Stromal Vascular Fraction (SVF) and hydrogel on osteoarthritis (for cartilage defects).
  • A comparative study of Chithra HASi granules (Hydroxyapatite and Calciumphosphosilicate glass) and PRF in reconstruction of maxillary and mandibular benign cystic lesions.
  • Use of Stromal Vascular Fraction (SVF) in and indigenous developed cocktail for the regeneration of spinal cord injury model rats.
  • Stromal Vascular Fraction (SVF) and Chithra HASi granules in critical osseous defects in rats.
  • In vitro cytotoxic evaluation of Flowable hyaluronic acid – acellular Stromal Vascular Fraction (HAaSVF) for neural tissue engineering application (collaboration under visiting adjunct faculty program with Sree Chitra Tirunal Institute for Medical Sciences & Technology – Trivandrum.
  • Rheometric evaluation of flowable non cross-linked plant based hyaluronic acid (collaboration with VIT, Vellore
  • Regenerative endodontic procedures
Completed Projects
  • Genetic changes in oral cancer stem cells
    • Using karyotyping
    • Using FISH (fluorescent in situ hybridization)
  • Use of low level laser therapy on dental pulp stem cells for differentiation into osteogenic lineages.
  • Clinical applications of PRF and PRP in dentistry, dermatology and orthopedics
  • Estimation of the regenerative capacity of dental pulp stem cells.
  • Isolation and characterization of dental pulp stem cells
    • Permanent Tooth
    • Deciduous Tooth
    • Enumeration of dental pulp stem cells
    • Team formation for dental pulp stem cell banking using reversible hydrogel
  • Reconstruction of craniofacial bone defects with autologous human bone marrow stem cells and autogenous bone grafts.
Contact
Dr. P M Sunil – MDS, PhD

Director
Centre for Stem Cells & Regenerative Medicine
Sree Anjaneya Institute of Dental Sciences
Malabar Medical College Campus
Atholi, Kozhikode, Kerala
Mail: sunil@saids.edu.in

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